A novel ZEB1/HAS2 positive feedback loop promotes EMT in breast cancer
نویسندگان
چکیده
منابع مشابه
A novel ZEB1/HAS2 positive feedback loop promotes EMT in breast cancer
Cancer metastasis is the main reason for poor patient survival. Tumor cells delaminate from the primary tumor by induction of epithelial-mesenchymal transition (EMT). EMT is mediated by key transcription factors, including ZEB1, activated by tumor cell interactions with stromal cells and the extracellular matrix (ECM). ZEB1-mediated EMT and motility is accompanied by substantial cell reprogramm...
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1Experimental and Molecular Pathology, Institute of Pathology, Ludwig-Maximilians-University Munich, Munich, Germany. 2Institute of Molecular Immunology, Klinikum Rechts der Isar, Technical University Munich, Munich, Germany. 3Institute for Multiple Sclerosis Research and Department of Neuroimmunology, Gemeinnützige Hertie-Stiftung, and University Medical Center Göttingen, Göttingen, Germany. 4...
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ژورنال
عنوان ژورنال: Oncotarget
سال: 2017
ISSN: 1949-2553
DOI: 10.18632/oncotarget.14563